TCT-736 Markedly Reduced Platelet Inhibition with Clopidogrel Given To Patients Undergoing Therapeutic Hypothermia Post Cardiac Arrest

Antiplatelet effect of clopidogrel is reduced in patients treated with therapeutic hypothermia after cardiac arrest.

BACKGROUND The platelet inhibitor clopidogrel is administered to patients treated with therapeutic hypothermia following cardiac arrest due to acute coronary syndromes. Interactions with proton pump inhibitors and genetics are factors with a known potential to attenuate the platelet inhibition of clopidogrel. In patients treated with therapeutic hypothermia, reduced gastrointestinal function an...

Prognostication in Post Cardiac Arrest Patients Treated with Therapeutic Hypothermia

Therapeutic Hypothermia for Cardiac Arrest

In the era before Therapeutic Hypothermia (TH) was recommended and used as a therapeutic modality for out-of-hospital cardiac arrest (OHCA) patients, reported data suggests in-hospital mortality exceeded 58%.[1,2,3,4,5,6] Mortality after a sudden and unexpected cardiac arrest (CA) is high, and the chance of survival to hospital discharge has, until recently, remained unchanged.[7] In one report...

Therapeutic hypothermia in cardiac arrest.

Approximately 275 000 Europeans per year experience out-ofhospital cardiac arrest, with huge differences in survival ranging from more than 30% in some cities to just a few percent in others. The main cause of these significant survival differences is differences in overall quality of the treatment, both pre-hospital during resuscitation and in-hospital after return of spontaneous circulation. ...

Therapeutic hypothermia after cardiac arrest.

Recent evidence supports the use of therapeutic hypothermia after cardiac arrest. This article reviews recent published studies and describes the pathophysiology of hypothermia. Nurses need to understand the physiology of hypothermia to provide care for patients receiving therapeutic hypothermia. A suggested protocol is included to help manage the care of these patients.